Gastrointestinal Tract

Drugs affecting the stomach, intestines, liver, and digestion.

52 drugs target this system

Drugs Targeting Gastrointestinal Tract

Metformin

Glucophage, Fortamet, Glumetza +1

Metformin is a biguanide antidiabetic agent used as first-line therapy for type 2 diabetes mellitus. It works primarily by decreasing hepatic glucose production and improving insulin sensitivity.

AntidiabeticsSmall Molecule

Indications: Type 2 Diabetes Mellitus, Polycystic Ovary Syndrome (off-label)...

Omeprazole

Prilosec, Losec, Omesec

FDA Approved

Irreversibly blocks the hydrogen/potassium adenosine triphosphatase enzyme system (H+/K+ ATPase or gastric proton pump) of the gastric parietal cell, suppressing gastric acid secretion.

Proton Pump InhibitorsSmall Molecule

Indications: Gastroesophageal reflux disease (GERD), Peptic ulcer disease...

Pantoprazole

Protonix, Pantoloc

FDA Approved

Proton pump inhibitor for gastric acid suppression, used in GERD, erosive esophagitis, and Zollinger-Ellison syndrome.

Proton Pump InhibitorsSmall Molecule

Indications: Gastroesophageal reflux disease (GERD), Erosive esophagitis...

Linagliptin

Tradjenta, Trajenta

FDA Approved

DPP-4 inhibitor for type 2 diabetes. Unique among gliptins for primarily non-renal elimination, requiring no dose adjustment in kidney disease.

AntidiabeticsSmall Molecule

Indications: Type 2 diabetes mellitus (adjunct to diet and exercise)

Looking for patient-friendly information? Visit RemedyDoor for easy-to-read guides on treatments for the Gastrointestinal Tract system.