Central Nervous System

Drugs affecting the brain, spinal cord, and neural pathways.

89 drugs target this system

Drugs Targeting Central Nervous System

Sertraline

Zoloft

FDA Approved

Sertraline is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat major depressive disorder, panic disorder, OCD, PTSD, social anxiety disorder, and premenstrual dysphoric disorder.

SSRI AntidepressantsSmall Molecule
Indications: Major Depressive Disorder, Panic Disorder...

Ibuprofen

Advil, Motrin, Nurofen

OTC

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and anti-inflammatory effects. Available over-the-counter and by prescription.

NSAIDsSmall Molecule
Indications: Mild to moderate pain, Fever...

Gabapentin

Neurontin, Gralise, Horizant

FDA Approved

Binds to alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing excitatory neurotransmitter release. Exact mechanism not fully understood.

AnticonvulsantsSmall Molecule
Indications: Partial seizures (adjunctive therapy), Postherpetic neuralgia...

Escitalopram

Lexapro, Cipralex

FDA Approved

Selective serotonin reuptake inhibitor (SSRI). Potently and selectively inhibits neuronal reuptake of serotonin (5-HT), enhancing serotonergic neurotransmission.

SSRI AntidepressantsSmall Molecule
Indications: Major depressive disorder (MDD), Generalized anxiety disorder (GAD)...

Fluoxetine

Prozac, Sarafem

FDA Approved

Selective serotonin reuptake inhibitor (SSRI) and the first drug in its class, widely used for depression, OCD, and eating disorders.

SSRI AntidepressantsSmall Molecule
Indications: Major depressive disorder, Obsessive-compulsive disorder...

Duloxetine

Cymbalta, Irenka

FDA Approved

Serotonin-norepinephrine reuptake inhibitor (SNRI) used for depression, anxiety, diabetic neuropathy, fibromyalgia, and chronic musculoskeletal pain.

SNRI AntidepressantsSmall Molecule
Indications: Major depressive disorder, Generalized anxiety disorder...

Naproxen

Aleve, Naprosyn, Anaprox

OTC

Naproxen is a propionic-acid non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever.

NSAIDsSmall Molecule
Indications: Osteoarthritis, Rheumatoid arthritis...

Acetaminophen

Tylenol, Panadol

OTC

Acetaminophen is a widely used non-opioid analgesic and antipyretic for the relief of mild to moderate pain and fever. It has little anti-inflammatory activity.

Non-Opioid AnalgesicsSmall Molecule
Indications: Mild to moderate pain, Fever

Tramadol

Ultram, ConZip

FDA Approved

Tramadol is a centrally acting opioid analgesic with additional serotonin and norepinephrine reuptake inhibition, used for moderate to moderately severe pain.

Opioid AnalgesicsSmall Molecule
Indications: Moderate to moderately severe pain

Citalopram

Celexa

FDA Approved

Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat major depressive disorder.

SSRI AntidepressantsSmall Molecule
Indications: Major depressive disorder

Venlafaxine

Effexor, Effexor XR

FDA Approved

Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder.

SNRI AntidepressantsSmall Molecule
Indications: Major depressive disorder, Generalized anxiety disorder...

Looking for patient-friendly information? Visit RemedyDoor for easy-to-read guides on treatments for the Central Nervous System system.